Target Selection and Determination of Function in Structural Genomics
نویسندگان
چکیده
منابع مشابه
Methodologies for target selection in structural genomics.
As the number of complete genomes that have been sequenced keeps growing, unknown areas of the protein space are revealed and new horizons open up. Most of this information will be fully appreciated only when the structural information about the encoded proteins becomes available. The goal of structural genomics is to direct large-scale efforts of protein structure determination, so as to incre...
متن کاملTarget selection and deselection at the Berkeley Structural Genomics Center.
At the Berkeley Structural Genomics Center (BSGC), our goal is to obtain a near-complete structural complement of proteins in the minimal organisms Mycoplasma genitalium and M. pneumoniae, two closely related pathogens. Current targets for structure determination have been selected in six major stages, starting with those predicted to be most tractable to high throughput study and likely to yie...
متن کاملTSTMP: target selection for structural genomics of human transmembrane proteins
The TSTMP database is designed to help the target selection of human transmembrane proteins for structural genomics projects and structure modeling studies. Currently, there are only 60 known 3D structures among the polytopic human transmembrane proteins and about a further 600 could be modeled using existing structures. Although there are a great number of human transmembrane protein structure...
متن کاملDetermination of protein function, evolution and interactions by structural genomics.
The genome sequencing projects and knowledge of the entire protein repertoires of many organisms have prompted new procedures and techniques for the large-scale determination of protein structure, function and interactions. Recently, new work has been carried out on the determination of the function and evolutionary relationships of proteins by experimental structural genomics, and the discover...
متن کاملTarget selection for structural genomics based on ProtoNet classification
Motivation: Structural genomics projects aim to solve a large number of protein structures to eventually represent the entire protein space. To this end it is necessary to increase the rate at which new families, superfamilies and folds are discovered. To facilitate that, strategies to improve the selection of targets for structural determination are needed. An important component in the design...
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ژورنال
عنوان ژورنال: IUBMB Life (International Union of Biochemistry and Molecular Biology: Life)
سال: 2003
ISSN: 1521-6543,1521-6551
DOI: 10.1080/1521654031000123385